YOSHINORI OHSUMI, Ph.D.
Professor, Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan
For discoveries concerning the molecular basis of autophagy, a universal process by which cells digest their own organelles to generate life-saving energy during starvation.
Bert Vogelstein, M.D.
Clayton Professor of Oncology and Pathology, Johns Hopkins University, Director, Ludwig Center for Cancer Genetics & Therapeutics, Johns Hopkins Kimmel Cancer Center Investigator, Howard Hughes Medical Institute in Maryland, U.S.A.
For his breakthroughs in oncology re-search, which have spanned more than two decades and have formed the basis of modern cancer re-search.
Emmanuelle Charpentier, Ph.D.& Jennifer Doudna, Ph.D.
Jennifer Doudna, Ph.D.
Howard Hughes Medical Institute Investigator and Li Ka Shing Chancellor's Chair in Biomedical and Health Sciences, Professor of Biochemistry, Biophysics and Structural Biology, University of California, Berkeley, California, U.S.A.
Emmanuelle Charpentier, Ph.D.
Emmanuelle Charpentier, Ph.D. Hannover Medical School and Helmholtz Centre for Infection Research (HZI), Germany and The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, Umeå, Sweden.
For their co-discovery of a new method for precisely manipulating genetic information in ways that should produce new insights in health and disease, and may lead to the discovery of new targets for drug development.
David Julius, Ph.D.
Professor and Chair, Department of Physiology, University of California San Francisco, California, U.S.A.
For his discovery of the molecular mechanism that controls thermosensation (sensory perception of temperature) and elucidation of the role this mechanism plays in the sensation of acute and inflammatory pain.
Victor Ambros, Ph.D. & Gary Ruvkun, Ph.D.
Victor Ambros, Ph.D.
Professor of Molecular Medicine, University of Massachusetts Medical School, Massachusetts, U.S.A.
Gary Ruvkun, Ph.D.
Harvard Medical School Professor of Genetics at Massachusetts General Hospital, Massachusetts, U.S.A.
For their co-discovery of microRNAs (miRNAs) as central regulators of gene expression and development
Napoleone Ferrara, M.D.
Genentech Fellow, San Francisco, California, U.S.A.
For his research on angiogenesis, the process of new blood vessel formation that plays a key role in cancer proliferation and a number of other diseases.
Erik De Clercq, M.D., Ph.D. & Anthony S. Fauci, M.D.
Erik De Clercq, M.D., Ph.D.
Professor Emeritus, Rega Institute for Medical Research, Leuven, Belgium
Anthony S. Fauci, M.D.
Director, National Institute of Allergy and Infectious Diseases, the National Institutes of Health, Maryland, U.S.A.
For their pioneering work in understanding and combating viral diseases, particularly HIV/AIDS
Axel Ullrich, Ph.D.
Director of the Department of Molecular Biology, Max Planck Institute of Biochemistry, Munich , Germany.
For his pioneering work in applying molecular biology and molecular cloning to the discovery of protein therapeutics for the treatment of a wide range of diseases, including diabetes and cancer.
Marc Feldmann, FMedSci, FAA, FRS & SIR RAVINDER MAINI, FMEDSCI, FRCP, FRS
Kennedy Institute of Rheumatology, Imperial College, London, U. K.
For their role in the discovery of tumor necrosis factor-alpha as an effective therapeutic target for rheumatoid arthritis and other chronic inflammatory conditions.
Craig C. Mello, M.D.
Professor of Molecular Medicine at the University of Massachusetts Medical School, Worchester, Massachusetts, U. S. A.
For his role in the discovery of RNA interference and the elucidation of its biological functions.