Scientific Achievements

Dr. Paul Janssen was one of the most productive pharmaceutical researchers of the 20th century. During his career Dr. Paul and his team were responsible for the discovery of over 80 drugs, including 25 antipsychotic medicines. He and his team made discoveries in many areas, including anesthesia and pain management, psychiatry, mycology and gastroenterology. Among the discoveries to which he contributed are:

  • Discovery of HALDOL® (haloperidol), the first effective antipsychotic medicine.
  • Discovery of FENTANYL® and other anesthetics.
  • Discovery of RISPERDAL® (risperidone), the most widely prescribed atypical antipsychotic in the world.
  • Development of Tibo anti-HIV compounds.
  • Development of IMODIUM® (loperamide HCL), a widely used anti-diarrheal that can be lifesaving in the event of acute diarrhea
  • Development of VERMOX® (mebendazole), a vital drug for use in parasitic worm infections.
  • Development of a wide range of anti-fungal medications, including DAKTARIN® (miconazole nitrate), NIZORAL® (ketoconazole) and SPORANOX® (itraconazole).
  • Development of a wide range of medicines for research including anti-fungals, anti-psychotics, anti-histaminics, anti-neuroleptics.

Dr. Paul was the author of 468 scientific papers indexed in the Science Citation Index (SCI). He also authored many conference proceedings, book chapters, and papers in publications not indexed by the SCI.

As of January 2006, his 468 indexed papers have received 21,716 citations and continue to be cited heavily. In addition, Dr. Paul has co-authored papers with more than 850 different scientists.

Here is a list of Dr. Paul's 10 most highly cited papers, all of which have been cited over 300 times. Only about 0.15 percent of research papers published, reach this level of citation. To have published 10 papers in this group is remarkable. Two of them have been featured as Citation Classics in Current Contents, with commentary on the background to the paper from Dr. Paul.

 
  • Paper
    Citations

  • 1981 Life Sciences 28 (9): 1015-1022
    Leysen JE; Awouters F; Kennis L; Laduron PM; Vandenberk J; Janssen PAJ
    Receptor-Binding Profile Of R-41-468, A Novel Antagonist At 5-HT2 Receptors

    904

  • 1981 Journal Of Pharmacology And Experimental Therapeutics 218 (1): 217-230
    Vannueten JM; Janssen PAJ; Vanbeek J; Xhonneux R; Verbeuren TJ; Vanhoutte PM.
    Vascular Effects Of Ketanserin (R-41-468), A Novel Antagonist Of 5-HT2 Serotonergic Receptors

    705

  • 1990 Nature 343 (6257): 470-474
    Pauwels R; Andries K; Desmyter J; Schols D; Kukla MJ; Breslin HJ; Raeymaeckers A; Vangelder J; Woestenborghs R; Heykants J; Schellekens K; Janssen MAC ; Declercq E; Janssen PAJ
    Potent And Selective-Inhibition Of HIV-1 Replication Invitro By A Novel Series Of Tibo Derivatives

    634

  • 1965 Arzneimittel-Forschung 15 (2): 104-&Janssen PAJ;
    Niemegeers.CJ; Schellekens KH.
    Is It Possible To Predict Clinical Effects Of Neuroleptic Drugs (Major Tranquillizers) From Animal Data .I. Neuroleptic Activity Spectra For Rats (Citation Classic)

    507

  • 1963 Arzneimittel-Forschung-Drug Research 13 (6): 502
    Janssen PAJ; Niemegeers CJC; Dony JGH
    Inhibitory Effect Of Fentanyl And Other Morphine-Like Analgesics On Warm Water Induced Tail Withdrawal Reflex In Rats (Citation Classic)

    496

  • 1988 Journal Of Pharmacology And Experimental Therapeutics 244(2): 685-693
    Janssen PAJ; Niemegeers CJC; Awouters F; Schellekens KHL;Megens AAHP; Meert TF
    Pharmacology Of Risperidone (R 64 766), A New Antipsychotic With Serotonin-S2 And Dopamine-D2 Antagonistic Properties

    357

  • 1976 Cancer Research 36 (3): 905-916
    Debrabander MJ; Vandeveire RML; Aerts FEM; Borgers M; Janssen PAJ
    Effects Of Methyl [5-(2-Thienylcarbonyl)-1H-Benzimidazol-2-Yl] Carbamate, (R-17934-NSC-238159), A New Synthetic Antitumoral Drug, Interfering With Microtubules, On Mammalian-Cells Cultured Invitro

    352

  • 1968 Arzneimittel-Forschung 18 (3): 261-&
    Janssen PAJ; Niemegeers.CJ; Schellekens.KH; Dresse A; Lenaerts
    FM; Pinchard A; Schaper WKA; Vannueten.JM; Verbrugg.FJ
    Pimozide, A Chemically Novel Highly Potent And Orally Long-Acting Neuroleptic Drug .I. Comparative Pharmacology Of Pimozide Haloperidol And Chlorpromazine

    335

  • 1988 Journal Of Pharmacology And Experimental Therapeutics 247
    (2): 661-670 Leysen JE; Gommeren W; Eens A; Decourcelles DD ;
    Stoof JC; Janssen PAJ
    Biochemical Profile Of Risperidone, A New Antipsychotic

    322

  • 1994 Journal Of Molecular Biology 243 (3): 369-387
    Tantillo C; Ding JP; Jacobomolina A; Nanni RG; Boyer PL; Hughes SH; Pauwels R; Andries K; Janssen PAJ; Arnold E
    Locations Of Anti-AIDS Drug-Binding Sites And Resistance Mutations In The 3-Dimensional Structure Of HIV-1 Reverse-Transcriptase - Implications For Mechanisms Of Drug-Inhibition And Resistance

    310
Dr. Paul Janssen